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KMID : 0613820080180030403
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Journal of Life Science
2008 Volume.18 No. 3 p.403 ~ p.408
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Effect of Ethanol Extract from Peel of Citrus junos and Poncirus trifoliata on Antioxidant and Immune Activity
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Park Joon-Hee
Kang Byoung-Won
Kim Ji-Eun
Seo Min-Jeong
Lee Young-Chun
Lee Jai-Heon
Lim Hak-Seob
Choi Yung-Hyun
Joo Woo-Hong
Jeong Yong-Kee
Lee Bok-Kyu
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Abstract
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In this study, we compared with 80% ethanol extracts from peel of Poncirus trifoliata (PTP) and peel of Citrus junos (CJP) against antioxidant and immune activities. Total phenolics and flavonoids contents in PTP extracts were60.75 ±1.15 and 33.75±0.15 mg/l00 g, respectively, and those were lower than CJP extracts. Antioxidant activities of PTP were increased with the more concentration, and were similar to CJP. Antioxidant activities of PTP were increased with increasing of concentration, and were similar to those of CJP. The NO production in macrophage cell lines were increased in a dose-dependent manner, until 5 mg/ml of CJP and 1 mg/ml of PTP compared with control cells, but decreased at higher concentrations. The proliferation of mouse spleen cells were increased in a dose-dependent manner, until 1 mg/ml of CJP and PTP compared with control cells but decreased at higher concentrations. The NO production in macrophage cell lines treated with PTP and CJP were increased in a dose-dependent manner, compared with untreated control cells until the concentrations of mg/ml (CJP) and 1 mg/ml (PTP) but decreased at higher concentrations than that. The proliferation of mouse spleen cells treated with PTP and CJP were increased in a dose-dependent manner, compared with untreated control cells until the concentration of 1 mg/ml but decreased at higher concentrations than that.
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KEYWORD
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Citrus junos, Poncirus trifoliata, antioxidant activity, immune activity
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